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In resource-constrained settings, tuberculosis (TB) remains the leading cause of death in HIV-positive adults. In this session we will discuss three South African studies designed to inform strategies to reduce morbidity and mortality due to TB. In the TB Fast Track trial, we tested the effect of nurse-led empirical TB treatment on mortality among adult outpatients with advanced HIV disease; in the Lesedi Kamoso study we explored causes of death among TB Fast Track participants; and in the XPHACTOR study we tested ways to prioritise use of Xpert MTB/RIF among HIV clinic attendees. We will discuss the findings of these three studies and their implications for current practice for with respect to TB investigation and management among HIV-positive people.

07:00
THSA0701
TB fast track: testing the effect of nurse-led empirical TB treatment on mortality among adult outpatients with advanced HIV disease
Salome Charalambous, The Aurum Institute, South Africa
Mpho Tlali, South Africa
Slides
07:20
THSA0702
Lesedi Kamoso: exploring causes of death among TB Fast Track participants
Aaron Karat, LSHTM, United Kingdom
Slides
07:40
THSA0703
XPHACTOR: testing ways to prioritise use of Xpert MTB/RIF among HIV clinic attendees
Alison Grant, London School of Hygiene & Tropical Medicine,
Slides